600 692
patient selection domain
( Fig. 3). The majority of studies
(17/21 studies) were judged to be at low RoB for index test
and reference standard domains.
3.4.
DTA results
Table 1presents the DTA results for each study separately,
together with the number of patients included, D’Amico risk
classification, PLND template, median number of SNs and
LNs retrieved, and percentage of LN-positive patients who
only had metastatic SN(s). Only a few studies used the
standardized definitions and criteria for DTA; the majority
used nonstandardized definitions to calculate their DTA
elements, in which case the results were recalculated using
standardized definitions using the raw data provided. The
median NDR across studies was 4.1% (IQR 1.5–10.7%),
sensitivity 95.2% (IQR 81.8–100%), specificity 100% (IQR
95.0–100%), PPV 100% (IQR 87.0–100%), NPV 98.0% (IQR
[(Fig._3)TD$FIG]
Fig. 3 – Risk of bias for the studies included according to QUADAS-2. Reference numbers are as in
Table 1.
E U R O P E A N U R O L O G Y 7 1 ( 2 0 1 7 ) 5 9 6 – 6 0 5
600