601 692
Table 1 – Individual results for diagnostic test accuracy for all the studies included
aStudy
Pts
D’Amico risk
Template
Tracer
Median number (
n
)
DY NDR SSY SPY PPV NPV FP FN Mets in SN
(
n
)
groups
SNs
LNs
b(%)
(%)
(%)
(%)
(%)
(%)
(%)
(%)
only (%)
Van den Bergh 2015
[18]
74 Intermediate/high
sePLND
99m
Tc-NC
4
21
95.9
4.1
NR NR NR
81.4
NR NR
41.7
Brenot-Rossi 2008
[19]
100 All
ePLND
99m
Tc-NC
3
7
76.0
24.0
100 100 100 100
0
0
100
Fukuda 2007
[20]
42 All
ePLND
99m
Tc-phytate NR
26
95.5
4.5 91.7 96.7 91.7
96.7 3.3 8.3
69.2
Grasso 2016
[17]
43 All
lPLND
99m
Tc-NC
NR
NR
100
0
100 95.1 50.0 100
4.9
0
100
Hacker 2006
[21]
20 Intermediate/high
ePLND 99mTc-HSA
NR
14 (mean)
90.0 10.0 100 100 100 100
0
0
87.5
Hinev 2009
[22]26 High
ePLND 99mTc-NC
3 (mean)
13 (mean)
100
0
81.8 100 100
88.2 0
18.2
81.8
Kjolhede 2015
[24]83 High
ePLND 99mTc-NC
2.5 (open)
2.0 (lap)
19 (open)
11 (lap)
86.7
13.3
95.2 96.1 90.9
98.0 3.9
4.8
NR
Kleinjan 2014
[23]
40 Intermediate/high
ePLND ICG-
99m
Tc-NC 4
12
95.0
5.0
75.0
100 100
93.8 0
25.0
37.5
Manny 2014
[25]
50 All
ePLND ICG
NR
14 (mean)
76.0
24.0
100
100 100
100
0
0
100
Meinhardt 2008
[26]35 Intermediate/high
ePLND 99mTc-NC
NR
13 (mean)
82.9 17.1 100 93.8 92.9 100
6.3
0
NR
Miki 2016
[16]28 Intermediate/high
ePLND ICG
4.9
NR
96.4
3.6 100 100 100 100
0
0
66.7
Muck 2014
[27]819 All
ePLND 99mTc-NC
3.7
11
98.9
1.1
NR NR NR
97.1
NR NR
66.4
Nguyen 2016
[36]
12 Intermediate/high
ePLND ICG
15
NR
100
0
80
NR NR
87.5
NR
20
NR
Ponholzer 2012
[28]
54 Intermediate/high
ePLND 99mTc-NC
2.1
16
98.1
1.9 93.3 100 100
97.4 0
6.7
93.3
Rousseau 2014
[29]
203 Intermediate/high
ePLND 99mTc-sulfur
5.6 (mean)
34 (mean)
96.1
3.9
91.4
100 100
98.2
0
8.6
57.1
Schilling 2010
[30]463 All
lPLND
99mTc-NC
3
13
89.2
10.8
50.0 98.0 55.6
97.5 2.0 50.0
NR
Silva 2005
[31]
23 All
ePLND 99mTc-sulfur
3.4 (mean)
14 (mean)
91.3
8.7 50.0 94.7 50.0
94.7 5.3 50.0
33.3
Stanik 2014
[32]80 Intermediate/high
ePLND 99mTc-NC
4
17
97.5
2.5 89.3 92.0 86.2
93.9
8.0 10.7
56.0
Weckermann 2007
[33]228 High
ePLND 99mTc-NC
7
18
100
0
97.6 91.7 87.2
98.5 8.3 2.4
72.9
Winter 2014
[34]
20 Intermediate/high
ePLND SPION
7
24
89.5
10.5 100 100 100 100
0
0
100
Yuen 2015
[35]
66 All
ePLND ICG
4
22
97.0
3.0 100 100 100 100
0
0
100
Pts = patients; SN = sentinel nodes; LN = lymph nodes; DY = diagnostic yield; NDR = nondiagnostic rate; SSY = sensitivity; SPY = specificity; PPV = positive predictive value; NPV = negative predictive value; FP = false
positive ratye; FN = false negative rate; Mets = metastases; PLND = pelvic lymph node dissection; sePLND = superextended PLND; ePLND = extended PLND; lPLND = limited PLND; NC = nanocolloid; NR = not reported;
HSA = human serum albumin; lap = laparoscopic; ICG = indocyanine green; SPION = superparamagnetic iron oxide particles.
a
Values in italics were recalculated from the raw data using standardized definitions of diagnostic accuracy elements. Values in bold were reported by the authors using standardized definitions of diagnostic accuracy
elements.
b
Lymph nodes including sentinel nodes.
E U R O P E A N U R O L O G Y 7 1 ( 2 0 1 7 ) 5 9 6 – 6 0 5
601