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13.

Conclusions

The present text represents a summary of the 2016 EAU

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-

ESTRO-SIOG PCa

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Guidelines. For more detailed information

and a full list of references, refer to the full-text version

(ISBN 978-90-79754-71-7), available at the EAU Web site

( http://uroweb.org/guideline/prostate-cancer/ ).

Author contributions:

Nicolas Mottet had full access to all the data in the

study and takes responsibility for the integrity of the data and the

accuracy of the data analysis.

Study concept and design:

Mottet, Cornford.

Acquisition of data:

Mottet, Bolla, De Santis, Henry, Joniau, Lam, Mason,

Matveev, Moldovan, van den Bergh, Van den Broeck, van der Poel, van

der Kwast, Rouvie`re, Wiegel, Cornford.

Analysis and interpretation of data:

Mottet, Bolla, Briers, De Santis, Henry,

Joniau, Lam, Mason, Matveev, Moldovan, van den Bergh, van der Poel,

van der Kwast, Rouvie`re, Wiegel, Cornford.

Drafting of the manuscript:

Mottet.

Critical revision of the manuscript for important intellectual content:

Mottet, Bellmunt, Bolla, Briers, Cumberbatch, De Santis, Fossati, Gross,

Henry, Joniau, Lam, Mason, Matveev, Moldovan, van den Bergh, Van den

Broeck, van der Poel, van der Kwast, Rouvie`re, Schoots, Wiegel, Cornford.

Statistical analysis:

None.

Obtaining funding:

None.

Administrative, technical, or material support:

None.

Supervision:

Mottet.

Other (specify):

None.

Financial disclosures:

Nicolas Mottet certifies that all conflicts of interest,

including specific financial interests and relationships and affiliations

relevant to the subject matter or materials discussed in the manuscript

(eg, employment/ affiliation, grants or funding, consultancies, honoraria,

stock ownership or options, expert testimony, royalties, or patents filed,

received, or pending), are the following: Nicolas Mottet receives grants/

research support from Takeda Pharmaceutical, Millennium, Astellas,

Pierre Fabre, Sanofi, and Pasteur. He receives honoraria or consultation

fees from Takeda Pharmaceutical, Millennium,

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Janssen, Astellas, BMS,

Bayer, Ipsen, Ferring, Novartis, Nucle´tron, Pierre Fabre, Sanofi, and

Zeneca. Joaquim Bellmunt is a company consultant for Janssen, Astellas,

Pierre Fabre, Genentech, Merck, Ipsen, Pfizer, Novartis and Sanofi

Aventis. He has received research support from Takeda, Novartis and

Sanofi and received travel grants from Pfizer and Pierre Fabre. Michel

Bolla receives company honoraria from Ipsen and Astra Zeneca, is a

company consultant for Janssen, and receives travel grants from Janssen,

AstraZeneca, and Astellas. Erik Briers is a liaison officer for the European

Prostate Cancer Coalition, a member of the ethics committee/ patient

advisory group for REQUITE (Validating predictive models and

biomarkers of radiotherapy toxicity to reduce side effects and improve

quality of life in cancer survivors), member of ESR-PAG (patient advisory

group on medical imaging), member of the Skeletal Care Academy, and

member of the European Medicines Agency’s Patients’ and Consumers’

Working Party. Maria De Santis is a company consultant for Glaxo Smith

Kline, Janssen, Bayer, Novartis, Pierre Fabre, Astellas, Amgen, Eisai Inc.,

ESSA, Merck, and Synthon. She receives company speaker honoraria

from Pfizer, Takeda, Sanofi Aventis, Shionogi, Celgene, and Teva

OncoGenex, participates in trials for Pierre Fabre, Astellas, and Roche,

and receives fellowships and travel grants from Bayer, Novartis, Ferring,

Astellas, Sanofi Aventis, and Janssen. She receives grants/research

support from Pierre Fabre and honoraria from AstraZeneca, participates

in trials for Exelixis, Bayer, and Roche, and is a company consultant for

Synthon. Steven Joniau is a company consultant for Astellas, Ipsen, Bayer,

Sanofi, and Janssen. He receives company honoraria from Astellas,

Amgen, Bayer, Sanofi, Janssen, and Ipsen, participates in trials for

Astellas, Bayer, and Janssen, receives fellowships and travel grants from

Astellas, Amgen, Bayer, Sanofi, Janssen, Ipsen, and Pfizer. Thomas B. Lam

is a company consultant for Pfizer, GSK, Astellas, and Ipsen, receives

company speaker honoraria from Pfizer, GSK, Astellas, and Ipsen.

Malcolm D. Mason is a company consultant for Bristol-Myers Squibb,

Janssen, Bayer, Sanofi, and Dendreon, and he receives company speaker

honoraria from Takeda and Bayer. Seva Matveev participates in trials for

Astellas, Pfizer, and Novartis, and receives company speaker honoraria

from Sanofi and Astellas. Henk G. van der Poel is a company consultant

for Intuitive Surgical and participates in trials for Astellas and Steba

Biotech. He receives grants/research support from Astellas. Olivier

Rouvie`re is a company consultant for EDAP-TMS, Bracco, and Philips. He

receives company speaker honoraria from EDAP-TMS and Bracco and

participates in trials for EDAP-TMS and Bracco. Thomas Wiegel receives

company speaker honoraria from Astellas, Takeda, Hexal, Ipsen, Janssen-

Cilac, and Ferring. Philip Cornford is a company consultant for Astellas,

Ipsen and Ferring. He receives company speaker honoraria from Astellas,

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Janssen, Ipsen and Pfizer and participates in trials from Ferring, and

receives fellowships and travel grants from Astellas and

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Janssen. Marcus

G. Cumberbatch, Nicola Fossati, Tobias Gross, Ann M. Henry, Paul L.

Moldovan, Ivo G. Schoots, Roderick C.N. van den Bergh, Thomas Van den

Broeck, and Theo van der Kwast have nothing to disclose.

Funding/Support and role of the sponsor:

None.

References

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[2] Oxford Centre for Evidence-Based Medicine – levels of evidence

(March 2009). Centre for Evidence-Based Medicine Web site.

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Albright F, Stephenson RA, Agarwal N, et al. Prostate cancer risk prediction based on complete prostate cancer family history. Pros- tate 2015;75:390–8

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Hemminki K. Familial risk and familial survival in prostate cancer. World J Urol 2012;30:143–8.

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Castro E, Goh C, Leongamorniert D, et al. Effect of BRCA mutations on metastatic relapse and cause-specific survival after radical treatment for localised prostate cancer. Eur Urol 2015;68:186–93.

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Castro E, Goh C, Olmos D, et al. Germline BRCA mutations are associated with higher risk of nodal involvement, distant metasta- sis, and poor survival outcomes in prostate cancer. J Clin Oncol 2013;31:1748–57.

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